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Creation Ministry provides the science and Scripture of the Genesis creation and global flood

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      • Movie Review: First Man
      • Natural Selection
      • Were The Days Of Creation 24 Hours Long?
      • Does Isaiah 40:22 Say The Earth Is A Ball?
      • Was Genesis 7 A Global Flood Or A Local Flood?
      • How Dangerous is Evolution to Salvation?
      • The Lie of Evolution with the Sclera
      • What is the Age of a Spiral Galaxy?
      • Transitional Fossils
      • Homo naledi
      • Australopithecus boisei
      • How millions of years changed to thousands
      • Circular Reasoning of Deep Time
      • The amazing diversity, beauty, and enigmatic genome of Diatoms
      • Origin of the Laws and Constants in the Universe
      • Circular Reasoning
      • Homo naledi
      • Australopithecus boisei
      • Genetically identical twins – but not so identical traits
      • How millions of years changed to thousands
      • How to Debunk Evolution
      • How to Debunk Evolution
      • Origin of the Laws and Constants in the Universe
      • Transitional Fossils
      • Seven things Darwin didn’t tell you
      • The amazing diversity, beauty, and enigmatic genome of Diatoms
      • The End Product of Evolution by Bill Nye
      • The End Product of Evolution by Bill Nye
      • The existing species concept called into question
      • There are no mechanisms for macroevolution
      • There are no mechanisms for macroevolution
      • Trust in GOD
      • The spin of the Earth is slowing
      • Evolution Debunked
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How to debunk the billions of years required by evolutionists.

Evolution requires hundreds of millions of years to allegedly have enough time for creatures to change kinds (evolve). Thus, when their pseudo-evidence is debunked, then they are exposed as believing in error. One bit of pseudo-evidence they routinely cite is the many layers of the crust. They'll explain that the layers deposited over 100,000 to million years for each layer. And for this reason, the many layers represent hundreds of millions of years. This is wrong for several reasons: 1. When soil is deposited by the slow natural uniformitarian process, it doesn't exclusively deposit only sand for 100,000 years, then limestone for the next million years, then mud with biomass for a million years, then mud without biomass for a million years, and so forth. No, all the soil sediment is mixed together. But when we look at the crust of the earth, the soil is in layers and segregated. This proves that the soil was once mixed together in a global flood, then as the soil settled, it settled according to density and formed layers. We can test this by mixing soil in water, then let it settle. 100% of the time the soil will settle in layers based on its density. Therefore, the layers of the crust is proof positive that the soil came quickly, was mixed together in a global flood, and then settled according to density. Based on the scientific method, we are able to observe that the Bible's global Flood matches perfectly with the empirical data of the soil in the crust, and that the slow deposit hypothesis that evolutionists use (uniformitarian) is incongruous with the observable evidence. Furthermore, we can test that soil settles in water in layers, just as the Biblical Flood caused, and each test testifies against the old age belief required to support evolution. 2. Meteorites usually get burned up in the atmosphere. However, roughly ~50,000 meteorites hit Earth each year. But did you know that there are no meteorites found in the lower layers of the crust. If evolutionary geologists are correct, and each layer is estimated to be 100,000 to million years old, then there should be ~5 billion meteorites per layer. Therefore, either no meteorites hit the earth for 100s of millions of years, or the layers of the crust came quickly from the global Flood of Genesis. The only logical conclusion is that the soil came quickly, and for this reason alone, there is not enough time for evolution. 3. There are no erosion marks between each layer. The layers are uniformly deposited without the usual erosion marks that comes from rain. Thus, either there was no rain on the earth while each layer was slowly being deposited over millions of years, or the layers came quickly from the catastrophic Flood of Genesis and the soil settled in layers according to their density. And for this reason, the soil was deposited quickly to account for no erosion marks from rain. That is, the Genesis catastrophic Flood. 4. Polystrata petrification and fossilization. There are observable evidences of petrified trees that transcend what evolutionary geologist call millions of years. No tree will wait around for the layers to slowly accumulate. Once the first layer comes, the tree will die and decay to dust before the second layer could finish. Thus, each petrified tree transcending through multiple layers represents that the soil came quickly, not over millions of years. And it's even worse considering the fragile marine life found transcending through multiple layers. This is proof positive that the layers came quickly from the Global flood and settled around the tree or fish. 5. We observe looking at the crust that there are examples of many layers that have bended from tectonic plates colliding. However, the bends in the layers represents that the soil was hot, malleable, and not hard as seen today. This evidence stands against the slow deposit belief because of the lack of cracks in the layers, and the visible bending of the layers. This supports the layers came quickly and settled while being warm from the catastrophic global flood. And not cold over millions of years. Therefore, the only logical conclusion is that the slow deposit hypothesis of evolution's uniformitarian theory is completely in error, and the Bible's catastrophic global Flood is in perfect harmony with science and best explains the observable evidence. This is a summary of a couple of pages in my book that is 420 pages. wpbeginner'/>
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Tag: transcription factors

There are no mechanisms for macroevolution

Epigenetic markers strongly affect binding of transcription factors

Epigenetic Marks Shun Some Transcription Factors, Embrace Others

Excerpt: “The same epigenetic marks can be read as “keep off” or “welcome,” depending on what DNA-binding protein, or transcription factor, is doing the reading. These marks, methylated cytosine and guanine dinucleotides (mCpGs), normally indicate which portions of the genome are inactive. But new findings from a systematic study of hundreds of transcription factors suggest that mCpGs may play a more subtle role in gene regulation.

In this new study, scientists based at Karolinska Institutet systematically analyzed the binding specificities of transcription factors to DNA that was marked by mCpGs, as well as to DNA that was unmarked by mCpGs. The observed that mCpGs can influence binding of most transcription factors to DNA—in some cases negatively and in others positively.

Interestingly, many of the transcription factors that prefer to bind to mCpG sites appear to be important to development. This finding may inform future analyses of the role of DNA methylation on cell differentiation, chromatin reprogramming, and transcriptional regulation.

The results pave the way for cracking the genetic code that controls the expression of genes, and will have broad implications for the understanding of development and disease. The availability of genomic information relevant to disease is expanding at an exponentially increasing rate.

“This study identifies how the modification of the DNA structure affects the binding of transcription factors, and this increases our understanding of how genes are regulated in cells and further aids us in deciphering the grammar written into DNA,” noted Professor Taipale.””

Excerpt from the original study:

“One shortcoming is the lack of knowledge about DNA binding specificities (motifs) for hundreds of the estimated ~1600 human transcription factors. Another is how transcription factor binding is modulated by “epigenetics”—a contentious term that refers to heritable states of both cells and organisms, as well as the covalent chemical modifications of DNA and protein that often provide the underlying mechanism. DNA methylation at cytosine and guanine dinucleotides (mCG) satisfies most views of epigenetics, as it is inherited across cell divisions and functions in imprinting (parent-of-origin–dependent gene expression). On page 502 of this issue, Yin et al. provide a comprehensive look at the extent to which human transcription factor binding is affected by mCG, and make a striking finding: Many homeodomain transcription factors—perhaps the best characterized developmental regulators in biology can bind to specific methylated DNA sequences.

More generally, the study of Yin et al. contributes a unique perspective to evaluating how transcription factors bind DNA. Transcription factor motif modeling is critical for the study of global gene regulation, allowing us to predict potential binding sites in the genome. Given that so many transcription factors are affected by chemical modifications to DNA, we are now faced with a clear necessity to incorporate DNA methylation into motif models, and a new type of data from which to learn to read the genome the way transcription factors do.”

My comment: This study confirms my previous claims about factors affecting phenotypes of organisms and observed changes in nature. Alterations in organisms are based on epigenetic factors and designed mechanisms mediated by nutrition, stress, climate and other environmental factors. Even one addition or deletion of one methyl group on a gene might have a significant influence on cell activity and identity. Random mutations or natural selection have no role in biodiversity. There are no mechanisms for large scale evolution. Everything points to God’s design and creation.

Posted on May 6, 2017Author Tomi AaltoTags alternative splicing, CpG methylation, epigenetics, protein binding, transcription factors
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